Does anyone no anything about this disease?

okay this is a disease that affects your feet but not your teeth so dont get it mixed up




















shark Marie tooth disease

Does anyone no anything about this disease?
I believe you're asking about: Charcot-Marie-Tooth disease???





If so, click on the link and read.......


http://www.clevelandclinic.org/health/he...
Reply:the correct spelling is Charcot-Marie-Tooth Disease.


It is actually many different types of Hereditary Motor and Sensory Neuropathy.


Charcot, Marie and Tooth are the people that described it in 1886. Causes loss of muscle mass, and sensation more in the feet but can also effect the hands in advanced disease. Different genes mutation that cause the different types of this disease lead to damage of the nerve fiber, either because the schawn cells (insulating the neuronal axon) dies or the axon itself dies.





Symptoms usually begin in late childhood or early adulthood.


- foot drop ( early )


- hammer toe, (toes are always curled)


- Wasting of muscle in the lower parts of the legs ("stork leg" or "inverted bottle")


- Weakness in the hands and forearms (later in life )


- Breathing, hearing, vision, neck and shoulder muscles.


- Scoliosis is common.


- Hip sockets can be malformed.


- GI problems


- chewing, swallowing, and speaking (as vocal cords atrophy).


- pregnancy and extreme emotional states can make it worse





Diagnosis: EMG studies and biopsy





No real cure is available at this time, but surgery can help compensate for the joint deformities.
Reply:I believe you mean...Charcot-Marie-Tooth disease is a group of progressive disorders that affect the peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles as well as sensory cells that detect sensations such as touch, pain, heat, and sound.





Symptoms of Charcot-Marie-Tooth disease usually begin in adolescence or early adulthood, but onset may occur anytime from early childhood to mid-adulthood. Symptoms vary in severity. Some people never realize they have the disorder, but most have a moderate amount of physical disability, and a small percentage of people experience severe weakness. Many people with this disorder lead active lives and have normal life expectancies.





Typically, the earliest symptoms involve muscle weakness in the feet, which can cause foot abnormalities such as high arches (pes cavus) or curled toes (hammer toes). It may become difficult to hold up the foot or to walk on the heel of the foot. These difficulties may cause a higher than normal step (or gait) and can increase the chance of ankle injuries and tripping. As the disease progresses, muscles in the lower legs usually weaken, but leg and foot problems rarely require the use of a wheelchair.





Later symptoms may include muscle weakness in the hands, causing difficulty with daily activities such as writing, fastening buttons, and turning doorknobs. Because signals to sensory cells can be disrupted in Charcot-Marie-Tooth disease, people with this disorder may also notice some numbness, feel pain in the feet and lower legs, or experience a decreased sensitivity to heat and cold. In rare cases, sensory loss can include gradual hearing impairment and deafness.





Different types of Charcot-Marie-Tooth disease can be distinguished by the abnormality that disrupts nerve function and by the genetic cause. Type X Charcot-Marie-Tooth disease is caused by mutations in a gene on the X chromosome, one of the two sex chromosomes. Type 1 Charcot-Marie-Tooth disease is characterized by abnormalities in myelin, the protective substance that covers nerve cells. Type 2 Charcot-Marie-Tooth disease is characterized by abnormalities in the fiber, or axon, that extends from a nerve cell and transmits nerve impulses. In intermediate forms of Charcot-Marie-Tooth disease, abnormalities occur in axons and myelin. Type 4 Charcot-Marie-Tooth disease affects either the axon or myelin. Types 1, 2, 4, and intermediate forms are further categorized by subtypes (such as 1A, 2A, 4A). Subtypes are distinguished by the specific gene that is altered.





No universal system is used to classify types of Charcot-Marie-Tooth disease, and sometimes other names are used to describe this disorder. For example, Roussy-Levy syndrome is a form of type 1 Charcot-Marie-Tooth disease (type 1B). Dejerine-Sottas syndrome is a severe, early childhood form of Charcot-Marie-Tooth disease that may be type 1 or type 4 (depending on the specific gene that is altered).




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